Britta Stordal

Senior Lecturer

Natural Sciences

Middlesex University

Ovarian Cancer, Drug Resistance, Platinum Chemotherapy, BRCA1, Parp Inhibitors, ABC Transporters

I am a cell biologist who specialises in drug response and drug resistance to chemotherapy drugs in ovarian cancer. I have experience studying the following biological pathways, DNA damage including BRCA1 mutation and methylation, cell cycle, glutathione metabolism and ABC drug transporters. I am currently investigating mechanisms of resistance to platinum, taxane and parp inhibitors in ovarian cancer. I am also a systematic reviewer active in the Cochrane Collaboration. I am currently writing a Cochrane Review “Taxane monotherapy for the treatment of platinum pre-treated epithelial ovarian cancer”. I have used my work in systematic reviews as a translational bridge between basic laboratory science and clinical trials.

BMedSci(Hons1a) - University of Technology, Sydney. PhD - University of Sydney PGDip Statistics - Trinity College Dublin PGDip Higher Education - Trinity College Dublin

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Latest Additions

  1. Busschots, Steven and O'Toole, Sharon and O'Leary, John J. and Stordal, Britta K. (2015) Non-invasive and non-destructive measurements of confluence in cultured adherent cell lines. MethodsX, 2 . pp. 8-13. ISSN 2215-0161
  2. McEvoy, Lynda M. and O'Toole, Sharon A. and Spillane, Cathy D. and Martin, Cara M. and Gallagher, Michael F. and Stordal, Britta K. and Blackshields, Gordon and Sheils, Orla and O'Leary, John J. (2015) Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer. BMC cancer, 15 . ISSN 1471-2407
  3. D’Adhemar, Charles J. and Spillane, Cathy D. and Gallagher, Michael F. and Bates, Mark and Costello, Katie M. and Barry-O'Crowley, Jacqui and Haley, Kathryn and Kernan, Niamh and Murphy, Ciara and Smyth, Paul C. and O'Byrne, Ken and Pennington, Stephen and Cooke, Aoife A. and Ffrench, Brendan and Martin, Cara M. and O'Donnell, Dearbhaile and Hennessy, Bryan T. and Stordal, Britta K. and Finn, Stephen and McCann, Amanda and Gleeson, Noreen and D'Arcy, Tom and Flood, Brian and O'Neill, Luke A. J. and Sheils, Orla and O'Toole, Sharon and O'Leary, John J. (2014) The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer. PLoS One, 9 (6). ISSN 1932-6203
  4. Madden, Stephen F. and Clarke, Colin and Stordal, Britta K. and Carey, Mark S. and Broaddus, Russell and Gallagher, William M. and Crown, John and Mills, Gordon B. and Hennessy, Bryan T. (2014) OvMark: a user-friendly system for the identification of prognostic biomarkers in publically available ovarian cancer gene expression datasets. Molecular Cancer, 13 (241). ISSN 1476-4598
  5. Stordal, Britta K. and Davey, Ross A. (2009) ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair. Cancer Chemotherapy and Pharmacology, 63 (4). pp. 661-672. ISSN 0344-5704
  6. Busschots, Steven and O'Toole, Sharon and O'Leary, John J. and Stordal, Britta K. (2015) Carboplatin and taxol resistance develops more rapidly in functional BRCA1 compared to dysfunctional BRCA1 ovarian cancer cells. Experimental cell research, 336 (1). pp. 1-14. ISSN 0014-4827
  7. Lawlor, Denise and Martin, Patricia and Busschots, Steven and Thery, Julien and O'Leary, John J. and Hennessy, Bryan T. and Stordal, Britta K. (2014) PARP inhibitors as P-glyoprotein substrates. Journal of Pharmaceutical Sciences, 103 (6). pp. 1913-1920. ISSN 1520-6017
  8. Doherty, Ben and Lawlor, Denise and Gillet, Jean-Pierre and Gottesman, Michael and O'Leary, John J. and Stordal, Britta K. (2014) Collateral sensitivity to cisplatin in KB-8-5-11 drug-resistant cancer cells. Anticancer Research, 34 (1). pp. 503-507. ISSN 1791-7530
  9. McDermott, Martina and Eustace, Alex J. and Busschots, Steven and Breen, Laura and Crown, John and Clynes, Martin and O'Donovan, Norma and Stordal, Britta K. (2014) In vitro development of chemotherapy and targeted therapy drug-resistant cancer cell lines: a practical guide with case studies. Frontiers in oncology, 4 . ISSN 2234-943X
  10. Stordal, Britta K. and Timms, Kirsten and Farrelly, Angela and Gallagher, Danielle and Busschots, Steven and Renaud, Mickaël and Thery, Julien and Williams, Deborah and Potter, Jennifer and Tran, Thanh and Korpanty, Greg and Cremona, Mattia and Carey, Mark and Li, Jie and Li, Yang and Aslan, Ozlem and O'Leary, John J. and Mills, Gordon B. and Hennessy, Bryan T. (2013) BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation. Molecular Oncology, 7 (3). pp. 567-79. ISSN 1878-0261