The effects of creatine supplementation on cardiovascular, metabolic, and thermoregulatory responses during exercise in the heat in endurance-trained humans.

Kilduff, Liam P., Georgiades, Evelina, James, Nic ORCID: https://orcid.org/0000-0002-4181-9501, Minnion, R. H., Mitchell, M., Kingsmore, D., Hadjicharlambous, M. and Pitsiladis, Yannis P. (2004) The effects of creatine supplementation on cardiovascular, metabolic, and thermoregulatory responses during exercise in the heat in endurance-trained humans. International Journal of Sports Nutrition and Exercise Metabolism, 14 (4) . pp. 446-463. ISSN 1526-484X [Article]

Abstract

The effects of creatine (Cr) supplementation on cardiovascular, metabolic, and thermoregulatory responses, and on the capacity of trained humans to perform prolonged exercise in the heat was examined. Endurance-trained males (n = 21) performed 2 constant-load exercise tests to exhaustion at 63 ± 5 % VO in the heat (ambient temperature: 30.3 ± 0.5 °C) before and after 7 d of Cr (20 g × d-1 Cr + 140 g × d-1 glucose polymer) or placebo. Cr increased intracellular water and reduced thermoregulatory and cardiovascular responses (e.g., heart rate, rectal temperature, sweat rate) but did not significantly increase time to exhaustion (47.0 ± 4.7 min vs. 49.7 ± 7.5 min, P = 0.095). Time to exhaustion was increased significantly in subjects whose estimated intramuscular Cr levels were substantially increased (“responders”: 47.3 ± 4.9 min vs. 51.7 ± 7.4 min, P = 0.031). Cr-induced hyperhydration can result in a more efficient thermoregulatory response during prolonged exercise in the heat.

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