Physical mapping of the rat MHC class II genes shows a high level of inter-species conservation.

Carter, Clare A., Murphy, Gerrard, Fabre, John W. and Lund, Torben (1994) Physical mapping of the rat MHC class II genes shows a high level of inter-species conservation. Genomics, 22 (2) . pp. 451-455. ISSN 0888-7543 [Article] (doi:10.1006/geno.1994.1409)

Abstract

We report here a pulsed-field gel electrophoresis map of the rat major histocompatibility complex (MHC) class II region. Using probes for the recently discovered Tap-1 and Tap-2 genes and the different MHC class II genes, we found the gene order in the rat MHC (RT1) region to be RT1.H-Tap-1-Tap-2-Bb-Ba-Db-Da. Moreover, the distance between the Tap-1 and the RT1.Da genes is approximately 150 kb. This, together with recent mapping of the RT1 class III region, demonstrates an extensive colinearity in the MHC region of different species.

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