Association between large-scale genomic homozygosity without chromosomal loss and nonseminomatous germ cell tumor development

Lu, Yong-Jie, Yang, Jinshu, Noel, Elodie, Skoulakis, Spyros, Chaplin, Tracy, Raghavan, Manoj, Purkis, Trisha, Mcintyre, Alan, Kudahetti, Sakunthala C., Naase, Mahmoud, Berney, Dan, Shipley, Janet, Oliver, R. T. and Young, Bryan D. (2005) Association between large-scale genomic homozygosity without chromosomal loss and nonseminomatous germ cell tumor development. Cancer Research, 65 (20) . pp. 9137-9141. ISSN 1538-7445 [Article] (doi:10.1158/0008-5472.CAN-05-1697)

Abstract

The genotype of a tumor determines its biology and clinical behavior. The genetic alterations associated with the unique embryonal morphology of nonseminomatous subtypes of testicular germ cell tumors remain to be established. Using single nucleotide polymorphism microarray analysis, we found in all of the 15 nonseminomas analyzed, large-scale chromosomal homozygosities, most of which were not associated with relative chromosome loss. This unusual genotype, distinguishing nonseminoma from seminomas and other human tumors, may be associated with the special embryonal development morphologic transition of this malignancy. Based on these genetic data, we hypothesized a new potential origin of nonseminomas through sperm fusion. Nonrandom involvement of certain chromosomes also suggests that genes on these chromosome regions may play an important role in nonseminoma development.

Actions (login required)

View Item

Statistics

DownloadsShow export options

Export as CSVXMLJSON

Activity Overview

6 month trend

0Downloads

6 month trend

408Hits

Additional statistics are available via IRStats2.