The immunological analysis of epitopes on hCG
Lund, Torben and Delves, Peter J. (1998) The immunological analysis of epitopes on hCG. Reproduction: the official journal of the Society for the Study of Fertility, 3 (2) . pp. 71-76. ISSN 1470-1626 [Article] (doi:10.1530/ror.0.0030123)
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Abstract
The heterodimeric glycoprotein hormone, human chorionic gonadotropin, has been extensively characterized in terms of its recognition by mouse monoclonal antibodies. A number of different approaches have led to the definition of several epitope clusters on the surface of the molecule. These include epitopes located solely on the alpha- or beta-chain, some of which are masked when the two chains associate to form the holo-hormone. Additional epitopes comprise amino acids contributed by both the chains. In contrast to the extensive knowledge regarding B cell epitopes, the characterization of T cell epitopes on hCG has only recently begun to be explored.
| Item Type: | Article |
|---|---|
| Research Areas: | A. > School of Science and Technology > Natural Sciences |
| ISI Impact: | 9 |
| Item ID: | 3902 |
| Useful Links: | |
| Depositing User: | Mrs Sue Black |
| Date Deposited: | 02 Feb 2010 08:43 |
| Last Modified: | 30 Nov 2022 03:11 |
| URI: | https://eprints.mdx.ac.uk/id/eprint/3902 |
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