Comparison of edmonston-zagreb and schwarz strains of measles vaccine given by aerosol or subcutaneous injection

Khanum, Sultana, Garelick, Hemda ORCID: https://orcid.org/0000-0003-4568-2300, Nasir, Uddin, Mann, George and Tomkins, Andrew (1987) Comparison of edmonston-zagreb and schwarz strains of measles vaccine given by aerosol or subcutaneous injection. The Lancet, 329 (8525) . pp. 150-153. ISSN 0140-6736 [Article] (doi:10.1016/S0140-6736(87)91978-7)

Abstract

The serological response to measles vaccine was tested in Bangladesh in groups of infants aged 4-6 months who received equal doses of Edmonston-Zagreb or Schwarz vaccine by subcutaneous injection or by aerosol. Seroconversion (as measured by the haemagglutination test) occurred in 62% of infants receiving Edmonston-Zagreb strain by injection compared with only 37% of those receiving Schwarz strain. Seroconversion occurred in 35% of those given Edmonston-Zagreb and 34% of those given Schwarz vaccine by aerosol. Edmonston-Zagreb strain appears more effective than Schwarz vaccine in this population and further studies are indicated in other populations where early measles immunisation is desirable.

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