Diversity, transmission and selective pressure on the proteome of Pseudomonas aeruginosa

Shah, Ajit J. ORCID: https://orcid.org/0000-0002-2350-6384, Shah, Haroun N., Duncan, Louise and Ward, Malcom (2023) Diversity, transmission and selective pressure on the proteome of Pseudomonas aeruginosa. In: Microbiological Identification using MALDI-TOF and Tandem Mass Spectrometry Industrial and Environmental Applications. Shah, Haroun N., Gharbia, Saheer E., Shah, Ajit ORCID: https://orcid.org/0000-0002-2350-6384, Tranfield, Erika and Clive, Thompson, eds. Wiley, pp. 183-201. ISBN 978-1-119-81405-4. [Book Section] (Accepted/In press)

Abstract

In 1956, Williamson [1] contested the singular morphological description of Pseudomonas aeruginosa presented in Bergey’s Manual of Determinative Bacteriology, Such a limited description was proposed as inadequate at describing this diverse bacterial species. Traditional phenotypical methods for bacterial identification would reveal the phenotypic diversity in P. aeruginosa isolates, with the isolation of at least six colony types from different samples [2, 3]. Further variability would be unveiled in the morphologies, pigments, and substrate use, with reports of ‘atypical’ isolates. Nonetheless, these atypical traits were detected more and more frequently and instead pointed towards an extremely diverse species. This chapter examines the diversity of P. aeruginosa and its close relationship with the proteome. We discuss the cutting-edge mass spectrometry (MS) techniques that are continuing to reveal the extent and impact of proteomic diversity with respect to transmission and human infections of P. aeruginosa. In a parallel study, we undertake phylogenomic analysis of the species based upon its core protein sequences against eight other Pseudomonas species that may help to elucidate molecular markers that distinguish subtypes.

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