Regulatory and innovative mechanisms of bacterial quorum sensing-mediated pathogenicity: a review

Tripathi, Sonam, Purchase, Diane ORCID logoORCID: https://orcid.org/0000-0001-8071-4385, Govarthanan, Muthusamy, Chandra, Ram and Yadav, Sangeeta (2023) Regulatory and innovative mechanisms of bacterial quorum sensing-mediated pathogenicity: a review. Environmental Monitoring and Assessment, 195 (1) , 75. ISSN 0167-6369 [Article] (doi:10.1007/s10661-022-10564-0)

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Abstract

Quorum sensing (QS) is a system of bacteria in which cells communicate with each other; it is linked to cell density in the microbiome. The high-density colony population can provide enough small molecular signals to enable a range of cellular activities, gene expression, pathogenicity, and antibiotic resistance that cause damage to the hosts. QS is the basis of chronic illnesses in human due to microbial sporulation, expression of virulence factors, biofilm formation, secretion of enzymes, or production of membrane vesicles. The transfer of antimicrobial resistance gene (ARG) among antibiotic resistance bacteria is a major public health concern. QS-mediated biofilm is a hub for ARG horizontal gene transfer. To develop innovative approach to prevent microbial pathogenesis, it is essential to understand the role of QS especially in response to environmental stressors such as exposure to antibiotics. This review provides the latest knowledge on the relationship of QS and pathogenicity and explore the novel approach to control QS via quorum quenching (QQ) using QS inhibitors (QSIs) and QQ enzymes. The state-of-the art knowledge on the role of QS and the potential of using QQ will help to overcome the threats of rapidly emerging bacterial pathogenesis.

Item Type: Article
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Keywords (uncontrolled): Acylated homoserine lactone, Antibiotic sensitivity, Quorum Sensing - physiology, Virulence, Biofilms, Anti-Bacterial Agents - toxicity - metabolism, Quorum quenching, Humans, Biofilm formation, Pathogenicity, Quorum sensing, Environmental Monitoring, Bacteria, Anti-Infective Agents - metabolism, Auto-inducers
Research Areas: A. > School of Science and Technology > Natural Sciences
Item ID: 36813
Notes on copyright: This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use (https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10661-022-10564-0
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Depositing User: Jisc Publications Router
Date Deposited: 21 Nov 2022 13:08
Last Modified: 14 Dec 2022 17:20
URI: https://eprints.mdx.ac.uk/id/eprint/36813

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