Identification of human papillomavirus from super resolution microscopic images generated using deep learning architectures

Gao, Xiaohong W. ORCID: https://orcid.org/0000-0002-8103-6624, Wen, Xuesong ORCID: https://orcid.org/0000-0001-6518-8962, Li, Dong ORCID: https://orcid.org/0000-0001-9240-4173 and Liu, Xuefeng (2022) Identification of human papillomavirus from super resolution microscopic images generated using deep learning architectures. In: Deep Learning Applications, Volume 4. Wani, M. Arif and Palade, Vasile, eds. Advances in Intelligent Systems and Computing (AISC), 1434 . Springer. ISBN 9789811961526. [Book Section] (Accepted/In press)

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Abstract

This chapter presents five deep learning architectures for identification of Human papillomavirus (HPV) through generation of super resolution (SR) images by 4 folds. Specifically, generative adversarial deep learning networks (GAN) and a texture-based vision transformer (TTSR) architec-ture are applied and evaluated. As such, the generated SR images are able to display the same way a high-resolution image offers in identification of HPV like structures. In comparison, TTSR appears to perform the best with PSNR and SSIM being 28.70 and 0.8778 respectively whereas 25.80/0.7910, 18.35/0.5059. 30.31/0.8013, and 28.07/0.6074 are observed for the methods of RCAN, Pix2Pix, CycleGAN, and ESRGAN respective-ly. With regard to sensitivity and specificity when detecting HPV clus-ters, TTSR also leads with 83.6% and 83.33% respectively. It appears the computational SR images are capable to differentiate distinguishing fea-tures of HPV like particles and to determine the effectiveness of anti-HPV agents, holding promise providing insights into the formation stage of a cancer from HPV in the near future.

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