Hepatitis C viraemia in adults with type 2 autoimmune hepatitis.
Garson, Jeremy A., Lenzi, M., Ring, Christopher J. 
ORCID: https://orcid.org/0000-0002-9278-0942, Cassani, F., Ballardini, G., Briggs, M., Tedder, Richard S. and Bianchi, F. B.
(1991)
Hepatitis C viraemia in adults with type 2 autoimmune hepatitis.
Journal of medical virology, 34
(4)
.
pp. 223-6.
ISSN 0146-6615
[Article]
Abstract
Sera from 14 patients with type 2 autoimmune hepatitis (anti-LKM1 positive) were investigated for evidence of hepatitis C virus (HCV) infection. Antibodies to HCV were detected in 13 patients by both commercial and "in-house" ELISAs and also by a second generation recombinant immunoblot assay. Nine of the 13 (69%) anti-HCV positive patients were shown to be viraemic by a polymerase chain reaction-based assay for serum HCV RNA. Neither anti-HCV nor serum HCV RNA were detected in any of 6 controls with primary biliary cirrhosis or in 39 healthy blood donors. These findings strongly suggest a role for HCV in the pathogenesis of type 2 autoimmune hepatitis.
| Item Type: | Article |
|---|---|
| Research Areas: | A. > School of Science and Technology > Natural Sciences |
| Item ID: | 3332 |
| Useful Links: | |
| Depositing User: | Chris Ring |
| Date Deposited: | 03 Dec 2009 14:34 |
| Last Modified: | 13 Oct 2016 14:16 |
| URI: | https://eprints.mdx.ac.uk/id/eprint/3332 |
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