Hepatitis C viraemia in adults with type 2 autoimmune hepatitis.

Garson, Jeremy A., Lenzi, M., Ring, Christopher J. ORCID logoORCID: https://orcid.org/0000-0002-9278-0942, Cassani, F., Ballardini, G., Briggs, M., Tedder, Richard S. and Bianchi, F. B. (1991) Hepatitis C viraemia in adults with type 2 autoimmune hepatitis. Journal of medical virology, 34 (4) . pp. 223-6. ISSN 0146-6615 [Article]


Sera from 14 patients with type 2 autoimmune hepatitis (anti-LKM1 positive) were investigated for evidence of hepatitis C virus (HCV) infection. Antibodies to HCV were detected in 13 patients by both commercial and "in-house" ELISAs and also by a second generation recombinant immunoblot assay. Nine of the 13 (69%) anti-HCV positive patients were shown to be viraemic by a polymerase chain reaction-based assay for serum HCV RNA. Neither anti-HCV nor serum HCV RNA were detected in any of 6 controls with primary biliary cirrhosis or in 39 healthy blood donors. These findings strongly suggest a role for HCV in the pathogenesis of type 2 autoimmune hepatitis.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
Item ID: 3332
Useful Links:
Depositing User: Chris Ring
Date Deposited: 03 Dec 2009 14:34
Last Modified: 13 Oct 2016 14:16
URI: https://eprints.mdx.ac.uk/id/eprint/3332

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