A global review on short peptides: frontiers and perspectives

Apostolopoulos, Vasso ORCID: https://orcid.org/0000-0001-6788-2771, Bojarska, Joanna ORCID: https://orcid.org/0000-0001-9190-6913, Chai, Tsun-Thai ORCID: https://orcid.org/0000-0003-3716-1599, Elnagdy, Sherif ORCID: https://orcid.org/0000-0003-1331-8977, Kaczmarek, Krzysztof ORCID: https://orcid.org/0000-0001-8806-7792, Matsoukas, John, New, Roger ORCID: https://orcid.org/0000-0001-5625-7735, Parang, Keykavous ORCID: https://orcid.org/0000-0001-8600-0893, Lopez, Octavio Paredes ORCID: https://orcid.org/0000-0003-1583-7631, Parhiz, Hamideh, Perera, Conrad O., Pickholz, Monica, Remko, Milan, Saviano, Michele, Skwarczynski, Mariusz ORCID: https://orcid.org/0000-0001-7257-807X, Tang, Yefeng, Wolf, Wojciech M., Yoshiya, Taku ORCID: https://orcid.org/0000-0002-7276-5614, Zabrocki, Janusz, Zielenkiewicz, Piotr ORCID: https://orcid.org/0000-0001-8151-6874, AlKhazindar, Maha ORCID: https://orcid.org/0000-0002-3244-9377, Barriga, Vanessa, Kelaidonis, Konstantinos, Sarasia, Elham Mousavinezhad and Toth, Istvan (2021) A global review on short peptides: frontiers and perspectives. Molecules, 26 (2) , 430. pp. 1-45. ISSN 1420-3049 [Article] (doi:10.3390/molecules26020430)

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Abstract

Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes. Short peptides include fundamental molecular information for a prelude to the symphony of life. They have aroused considerable interest due to their unique features and great promise in innovative bio-therapies. This work focusing on the current state-of-the-art short peptide-based therapeutical developments is the first global review written by researchers from all continents, as a celebration of 100 years of peptide therapeutics since the commencement of insulin therapy in the 1920s. Peptide “drugs” initially played only the role of hormone analogs to balance disorders. Nowadays, they achieve numerous biomedical tasks, can cross membranes, or reach intracellular targets. The role of peptides in bio-processes can hardly be mimicked by other chemical substances. The article is divided into independent sections, which are related to either the progress in short peptide-based theranostics or the problems posing challenge to bio-medicine. In particular, the SWOT analysis of short peptides, their relevance in therapies of diverse diseases, improvements in (bio)synthesis platforms, advanced nano-supramolecular technologies, aptamers, altered peptide ligands and in silico methodologies to overcome peptide limitations, modern smart bio-functional materials, vaccines, and drug/gene-targeted delivery systems are discussed.

Item Type: Article
Keywords (uncontrolled): short peptides, constrained amino acids and peptide (bio)mimetics, drug design and drug/gene delivery, vaccines, aptamers, cell-penetrating peptides, synthesis, SARS-COV-2, cancer, bilayer interactions, altered peptide ligands, ant/super/agonists, diketopiperazine, cosmeceuticals
Research Areas: A. > School of Science and Technology
Item ID: 31844
Notes on copyright: Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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Depositing User: Jisc Publications Router
Date Deposited: 27 Jan 2021 13:21
Last Modified: 27 Jan 2021 13:21
URI: https://eprints.mdx.ac.uk/id/eprint/31844

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