Oral delivery of biologics via the intestine

New, Roger ORCID logoORCID: https://orcid.org/0000-0001-5625-7735 (2020) Oral delivery of biologics via the intestine. Pharmaceutics, 13 (1) , 18. pp. 1-21. ISSN 1999-4923 [Article] (doi:10.3390/pharmaceutics13010018)

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Abstract

Biologics are currently one of the most promising avenues for therapeutic interventions in conditions such as metabolic disease, ageing and inflammatory disorders, and for chronic ailments, oral delivery of such medicines has for years been recognised as an important goal. Despite decades of intensive research, oral delivery of biologics is only just starting to prove feasible. There has been much talk about the barriers to uptake of biologics, and indeed, one function of the intestine is to prevent, in one way or another, passage of unwanted materials across the gut, and yet, grams of biological agents both large and small pass across the intestinal cell wall every day. This review first describes the functioning of the gut under normal circumstances, then identifies the principle biological mechanisms which have been harnessed successfully, to date, to achieve oral uptake, outlining the pros and cons of each approach. Examples with different biologics are given, and information on result of the latest clinical trials is provided, where available.

Item Type: Article
Additional Information: This article belongs to the Special Issue Non-invasive Drug Delivery Systems.
Keywords (uncontrolled): Oral delivery, biologics, intestine, receptor-mediated uptake, permeation enhancers, paracellular transport, transcellular transport
Research Areas: A. > School of Science and Technology
Item ID: 31762
Notes on copyright: © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
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Depositing User: Jisc Publications Router
Date Deposited: 06 Jan 2021 11:14
Last Modified: 26 Jan 2021 16:13
URI: https://eprints.mdx.ac.uk/id/eprint/31762

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