Emerging applications in mass spectrometry imaging; enablers and roadblocks

Russo, Cristina ORCID: https://orcid.org/0000-0002-9776-8897, Heaton, Cameron ORCID: https://orcid.org/0000-0002-4479-3861, Flint, Lucy ORCID: https://orcid.org/0000-0001-6187-3081, Voloaca, Oana ORCID: https://orcid.org/0000-0003-0131-6907, Haywood-Small, Sarah ORCID: https://orcid.org/0000-0002-8374-9783, Clench, Malcolm Ronald ORCID: https://orcid.org/0000-0002-0798-831X, Francese, Simona ORCID: https://orcid.org/0000-0002-1381-1262 and Cole, Laura Margaret ORCID: https://orcid.org/0000-0002-2538-6291 (2020) Emerging applications in mass spectrometry imaging; enablers and roadblocks. Journal of Spectral Imaging, 9 , a13. pp. 1-21. ISSN 2040-4565 [Article] (doi:10.1255/jsi.2020.a13)

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Abstract

Mass spectrometry imaging (MSI) is a powerful and versatile technique able to investigate the spatial distribution of multiple non-labelled endogenous and exogenous analytes simultaneously, within a wide range of samples. Over the last two decades, MSI has found widespread application for an extensive range of disciplines including pre-clinical drug discovery, clinical applications and human identification for forensic purposes. Technical advances in both instrumentation and software capabilities have led to a continual increase in the interest in MSI; however, there are still some limitations. In this review, we discuss the emerging applications in MSI that significantly impact three key areas of mass spectrometry (MS) research—clinical, pre-clinical and forensics—and roadblocks to the expansion of use of MSI in these areas.

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