The association of parental genetic, lifestyle, and social determinants of health with offspring overweight

Graham, Catherine A.M., Pedlar, Charles, Hearne, Gary ORCID:, Lorente-Cebrian, Silvia, González-Muniesa, Pedro and Mavrommatis, Yiannis (2020) The association of parental genetic, lifestyle, and social determinants of health with offspring overweight. Lifestyle Genomics, 13 (2) . pp. 99-106. ISSN 2504-3188 [Article] (doi:10.1159/000505749)

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In the UK, the number of comorbidities seen in children has increased along with the worsening obesity rate. These comorbidities worsen into adulthood. Genomewide association studies have highlighted single nucleotide polymorphisms associated with the weight status of adults and offspring individually. To date, in the UK, parental genetic, lifestyle, and social determinants of health have not been investigated alongside one another as influencers of offspring weight status. A comprehensive obesity prevention scheme would commence prior to conception and involve parental intervention including all known risk factors.

This current study aims to identify the proportion of overweight that can be explained by known parental risk factors, including genetic, lifestyle, and social determinants of health with offspring weight status in the UK. Methods: A crosssectional study was carried out on 123 parents. Parental and offspring anthropometric data and parental lifestyle and social determinants of health data were self-reported. Parental genetic data were collected by use of GeneFiX saliva collection vials and genotype were assessed for brain-derived neurotrophic factor (BDNF) gene rs6265, melanocortin 4 receptor (MC4R) gene rs17782313, transmembrane protein 18 (TMEM18) gene rs2867125, and serine/threonine-protein kinase (TNN13K) gene rs1514175. Associations were assessed between parental data and the weight status of offspring.

Results: Maternal body mass index modestly predicted child weight status (p < 0.015; R2 = 0.15). More mothers of overweight children carried the MC4R rs17782313 risk allele (77.8%; p = 0.007) compared to mothers of normal-weight children. Additionally, fathers who were not Caucasian and parents who slept for < 7 h/night had a larger percentage of overweight children when compared to their counterparts (p = 0.039; p = 0.014, respectively).

Conclusion: Associations exist between the weight status of offspring based solely on parental genetic, lifestyle, and social determinants of health data. Further research is required to appropriately address future interventions based on genetic and lifestyle risk groups on a pre-parent cohort.

Item Type: Article
Research Areas: A. > School of Science and Technology > Design Engineering and Mathematics
A. > School of Science and Technology > London Sport Institute > Physiology at the London Sport Institute
Item ID: 29587
Notes on copyright: © 2020 The Author(s)
Published by S. Karger AG, Basel
This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BYNC-ND) ( Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.
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Depositing User: Gary Hearne
Date Deposited: 25 Mar 2020 08:42
Last Modified: 25 Mar 2020 08:54

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