Towards a system for tracking drug delivery using frequency excited gold nanoparticles

Neshatvar, Nazanin ORCID: https://orcid.org/0000-0002-0658-8883, Damaso, Rui, Seifnaraghi, Nima, Demosthenous, Andreas ORCID: https://orcid.org/0000-0003-0623-963X and Bayford, Richard ORCID: https://orcid.org/0000-0001-8863-6385 (2019) Towards a system for tracking drug delivery using frequency excited gold nanoparticles. Sensors, 19 (21) , 4750. pp. 1-9. ISSN 1424-8220 [Article] (doi:10.3390/s19214750)

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Abstract

Nanoparticle-based drugs are rapidly evolving to treat different conditions and have considerable potential. A new system based on the combination of electrical impedance tomography (EIT) imaging and a power amplifier with a RF coil has been developed to study the effect of gold nanoparticles (AuNPs) when excited in the MHz frequency range. We show that samples including AuNPs have a temperature increase of 1−1.5 °C due to the presence of RF excitation at 13.56 MHz which provides a higher rate of change for solutions without AuNPs. They also show more than a 50% increase in conductivity in difference imaging as the result of this excitation. The change for samples without AuNPs is 40%.

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