Potential interaction between natural compounds and chemotherapeutic drugs on leukaemia cell line

Osemeke, Cynthia, Garelick, Hemda ORCID: https://orcid.org/0000-0003-4568-2300, Wen, Xuesong ORCID: https://orcid.org/0000-0001-6518-8962 and Appiah, Sandra S. ORCID: https://orcid.org/0000-0002-7497-3388 (2015) Potential interaction between natural compounds and chemotherapeutic drugs on leukaemia cell line. In: 2015 Middlesex University Research Student Summer Conference, 17-18 June 2015, Middlesex University, London, United Kingdom. . [Conference or Workshop Item]

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Abstract

There is increasing evidence for the anticancer effect of natural compounds from plants which are valuable important resources for drug development. Some cancer patients choose to combine chemotherapy drugs with herbal medicines which could lead to possible herb-drug interactions. Herbs contain a mixture of natural compounds often poorly defined, which could produce beneficial effect and interact to give synergistic or opposing effects with chemotherapy drugs. In recent years, several naturally occurring compounds have shown inhibitory effect on the growth of different types of cancer cells but interaction of these compounds with chemotherapy drug has not being extensively studied. The aim of this research is to evaluate potential interaction of natural compounds (compounds and herbal extracts) and chemotherapy drugs on leukaemic cell lines. Herbal medicines, with potential anticancer effect will be selected through critical evaluation of existing literature. Their effect (alone and in combination with chemotherapy drugs) on cell proliferation and apoptosis will be investigated in vitro. Further analysis will be conducted to determine the mechanism of action of the active compounds and to evaluate if the combination of drugs have reduced or enhanced biological activity. The assays to be conducted include; caspases (3, 7, 8 and 9), cell cycle analysis, reactive oxygen species (ROS), nitric oxide species (NOS) assay. In addition, cytochrome P450 assays will provide data on the effect of the compounds on drug metabolizing enzymes. The findings from this research could provide relevant information on combination therapy.

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