The relationship between insulin and insulin-like growth factor binding protein-1 is modified by pre-eclampsia.
Anim-Nyame, N., Hills, Frank ORCID: https://orcid.org/0000-0001-8235-7545, Soorana, Suren R., Steer, P. J. and Johnson, M. J.
(2003)
The relationship between insulin and insulin-like growth factor binding protein-1 is modified by pre-eclampsia.
Gynecological endocrinology, 17
(6)
.
pp. 471-476.
ISSN 0951-3590
[Article]
(doi:10.1080/09513590312331290408)
Abstract
Insulin is the main negative regulator of insulin-like growth factor binding protein-1 (IGFBP-1) in the non-pregnant state. Although changes in insulin resistance and circulating level of IGFBP-1 occur in pre-eclampsia, little is known about the relationship between insulin and IGFBP-1 in pregnancies complicated by the disease. In this study, we have investigated whether the relationship between insulin and IGFBP-1 is modified by pre-eclampsia. Maternal levels of insulin and IGFBP-1 were measured, at 4-weekly intervals between 16 and 36 weeks' gestation, in plasma samples obtained from ten normal pregnant controls and ten women who developed pre-eclampsia. The controls were chosen to be similar in maternal age and booking body mass index to the pre-eclampsia group. Insulin levels increased in both the normal controls and the women who developed pre-eclampsia. The levels in pre-eclampsia were significantly greater than those in normal pregnancy at 32 and 36 weeks' gestation (p = 0.02 and 0.005, respectively). IGFBP-1 levels were unchanged in normal pregnancy and rose in pre-eclampsia. In normal pregnancy, insulin levels were inversely related to IGFBP-1 levels throughout. In women developing pre-eclampsia, the relationship between insulin and IGFBP-1 was negative at 16 weeks and positive from 24 weeks. These data suggest that whereas the inverse relationship between insulin and IGFBP-1 is maintained during normal pregnancy, this relationship is reversed in women who develop pre-eclampsia.
Item Type: | Article |
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Additional Information: | PubMed PMID: 14992166. |
Research Areas: | A. > School of Health and Education > Centre for Investigative and Diagnostic Oncology A. > School of Science and Technology > Natural Sciences A. > School of Science and Technology > Natural Sciences > Biomarkers for Cancer group A. > School of Science and Technology > Natural Sciences > Reproductive Biology group |
ISI Impact: | 0 |
Item ID: | 2500 |
Useful Links: | |
Depositing User: | Repository team |
Date Deposited: | 17 Jun 2009 13:05 |
Last Modified: | 13 Oct 2016 14:14 |
URI: | https://eprints.mdx.ac.uk/id/eprint/2500 |
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