Do the adult daughters of PCOS patients develop PCOS and is this due to an androgenized uterine environment-an online epidemiological survey

Ratajczak, Agnieszka, Iles, Ray Kruse and Wen, Xuesong ORCID logoORCID: (2016) Do the adult daughters of PCOS patients develop PCOS and is this due to an androgenized uterine environment-an online epidemiological survey. Reproductive System & Sexual Disorders: Current Research, 5 (2) , 1000167. pp. 1-5. ISSN 2161-038X [Article] (doi:10.4172/2161-038X.1000167)

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Objectives: Several inconsistent studies have investigated whether the uterine environment of androgenized pregnant women is a risk factor for an in-utero developmental imprinted predisposition towards subsequent
polycystic ovarian syndrome (PCOS) among their female offspring. These are difficult to compare due to variable parameters and subject selection criteria. Few epidemiological studies have analyzed the incidence of PCOS
amongst adult daughters of PCOS affected women previously. Our study aimed to investigate risk factors relating to the development of PCOS in the female offspring of PCOS patients.
Methods: We used a questionnaire to collect a mother-to-daughter medical history and relevant information, in order to understand risk factors, which might relate to the presence of PCOS daughters of PCOS patients.
Results: Of four hundred and one responses, 131 participants were included in the final analysis. There was no statistical association with the subsequent development of PCOS amongst female offspring of women with PCOS. However, there was a significantly higher prevalence of post-term birth among PCOS mothers. Nevertheless, the major determinant of risk of subsequent incidence of PCOS amongst daughters was a higher BMI, regardless of the mothers BMI.
Conclusion: Socio-economic family influences, affecting BMI, may be the reason for any mother to daughter association with PCOS.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
Item ID: 23724
Notes on copyright: Copyright: © 2016 Ratajczak A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Depositing User: Song Wen
Date Deposited: 05 Mar 2018 15:41
Last Modified: 29 Nov 2022 21:59

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