A systematic review and meta-analysis of lifestyle and body mass index predictors of successful assisted reproductive technologies

Purewal, Satvinder, Chapman, Sarah and van den Akker, Olga ORCID: https://orcid.org/0000-0002-3529-4358 (2019) A systematic review and meta-analysis of lifestyle and body mass index predictors of successful assisted reproductive technologies. Journal of Psychosomatic Obstetrics & Gynecology, 40 (1) . pp. 2-18. ISSN 0167-482X [Article] (doi:10.1080/0167482X.2017.1403418)

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Abstract

Objective: Lifestyle (smoking, drinking alcohol) and body mass index (BMI) predictors of successful outcomes in assisted reproductive technology (ART) treatments were examined in this meta-analysis.

Method: A bibliographic search was undertaken using six databases. The review was informed by PRISMA/MOOSE guidelines. Meta analytic data were analysed using random effects models.

Results: We included 77 studies examining effects of BMI, smoking and drinking alcohol. Patients with a BMI<24.9 were significantly more likely to achieve LB/pregnancy than with BMI>25 OR 1.219 (95% CI:1.128–1.319, z 4.971, p<.001; I2 53.779%, p .001). Non-smokers were significantly more likely to achieve a LB or pregnancy than smokers OR 1.457 (95% CI:1.228–1.727, z 4.324, p<.001; I2 51.883; p .001). Meta-regression revealed the number of embryos transferred significantly moderated the effects of smoking on ART outcomes, and there was a trend indicating primary infertility and high BMI were also significant moderators. The evidence for drinking alcohol was inconclusive due to the small number of studies.

Conclusions: This meta-analysis confirms that ART treatment success can be predicted with life-style factors. Further, non-smokers’ relative odds of pregnancy/live birth increase as more embryos were transferred but there was a trend that the odds of pregnancy/live birth decrease with primary infertility and high BMI.

Item Type: Article
Research Areas: A. > School of Science and Technology > Psychology > Applied Health Psychology group
Item ID: 23078
Notes on copyright: This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Psychosomatic Obstetrics & Gynecology on 27/11/2017, available online: http://www.tandfonline.com/10.1080/0167482X.2017.1403418
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Depositing User: Olga Van Den akker
Date Deposited: 05 Dec 2017 10:43
Last Modified: 09 Jun 2021 18:00
URI: https://eprints.mdx.ac.uk/id/eprint/23078

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