Amino acid neurotransmitters: separation approaches and diagnostic value

Shah, Ajit J. ORCID: https://orcid.org/0000-0002-2350-6384, Crespi, Francesco and Heidbreder, Christian A. (2002) Amino acid neurotransmitters: separation approaches and diagnostic value. Journal of Chromatography B, 781 (1-2) . pp. 151-163. ISSN 1570-0232 [Article] (doi:10.1016/S1570-0232(02)00621-9)

Abstract

Amino acids in the central nervous system can be divided into non-neurotransmitter or neurotransmitter depending on their function. The measurement of these small molecules in brain tissue and extracellular fluid has been used to develop effective treatment strategies for neuropsychiatric and neurodegenerative diseases and for the diagnosis of such pathologies. Here we describe the separation and detection techniques that have been used for the measurement of amino acids at trace levels in brain tissue and dialysates. An overview of the function of amino acid transmitters in the brain is given. In addition, the type of sampling techniques that are used for the determination of amino acid levels in the brain is described.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
Item ID: 22826
Depositing User: Ajit Shah
Date Deposited: 03 Nov 2017 12:00
Last Modified: 28 Nov 2019 14:02
URI: https://eprints.mdx.ac.uk/id/eprint/22826

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