Development of a high-pressure gradient pumping system for parallel liquid chromatography/mass spectrometry for the analysis of combinatorial libraries
Tolson, David, Organ, Andrew J. and Shah, Ajit J. 
ORCID: https://orcid.org/0000-0002-2350-6384
(2001)
Development of a high-pressure gradient pumping system for parallel liquid chromatography/mass spectrometry for the analysis of combinatorial libraries.
Rapid Communications in Mass Spectrometry, 15
(14)
.
pp. 1244-1249.
ISSN 0951-4198
[Article]
(doi:10.1002/rcm.359)
Abstract
Parallel liquid chromatography/mass spectrometer (LC/MS) systems such as the Micromass MUX™ have been commercially available for several years. Until recently, the LC pumping systems available have been a serious limitation to the more widespread adoption of such systems, particularly in good laboratory practice (GLP) environments. In this work, we compare the performance of the Jasco PAR-1500 pumping system, which delivers an equal gradient flow to eight individual flow channels, to that of a conventional system, where the flow is split post pump. Both systems were coupled to a Micromass LCT™ liquid chromatography/electrospray ionisation time-of-flight (LC/ESI-TOF) mass spectrometer equipped with a parallel MUX™ inlet system, used for the analysis of combinatorial libraries. In addition to flow stability, the Jasco system has resulted in a dramatic improvement in chromatographic performance. Copyright © 2001 John Wiley & Sons, Ltd.
| Item Type: | Article |
|---|---|
| Research Areas: | A. > School of Science and Technology > Natural Sciences |
| Item ID: | 22790 |
| Useful Links: | |
| Depositing User: | Ajit Shah |
| Date Deposited: | 01 Nov 2017 10:14 |
| Last Modified: | 28 Nov 2019 14:02 |
| URI: | https://eprints.mdx.ac.uk/id/eprint/22790 |
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