The evaluation of interdigitated array electrodes for the measurement of catecholamines and indoleamines
Senior, John, Shah, Ajit J. 
ORCID: https://orcid.org/0000-0002-2350-6384, Monteux, Cecile and de Biasi, Verner
(2001)
The evaluation of interdigitated array electrodes for the measurement of catecholamines and indoleamines.
Journal of Pharmaceutical and Biomedical Analysis, 24
(5-6)
.
pp. 843-848.
ISSN 0731-7085
[Article]
(doi:10.1016/S0731-7085(00)00551-3)
Abstract
The use of Interdigitated Array (IDA) Microelectrodes for detection of low levels of biogenic amines has been demonstrated in stationary solutions and flow systems [M. Morita, et al., Electrochemica Acta 42 (20--21) (1997) 3177--3183]. This technique is highly sensitive. We have evaluated this technology as applied to High Pressure Liquid Chromatography with Electrochemical Detection (HPLC-EC) for analysis of microdialysate and tissue samples. With this new technology we demonstrated a x 10 fold increase in sensitivity in comparison to our existing technology. We are now able to detect dopamine at a level of 53 x 10(-18) moles on column and serotonin at 26 x 10(-18) moles on column. This technology now permits analysis of biogenic amines in samples from brain areas not previously amenable to this type of experiment.
| Item Type: | Article |
|---|---|
| Research Areas: | A. > School of Science and Technology > Natural Sciences |
| Item ID: | 22789 |
| Useful Links: | |
| Depositing User: | Ajit Shah |
| Date Deposited: | 01 Nov 2017 10:13 |
| Last Modified: | 14 Nov 2022 16:07 |
| URI: | https://eprints.mdx.ac.uk/id/eprint/22789 |
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