A wideband low-distortion CMOS current driver for tissue impedance analysis

Constantinou, Loucas, Bayford, Richard ORCID logoORCID: https://orcid.org/0000-0001-8863-6385 and Demosthenous, Andreas (2015) A wideband low-distortion CMOS current driver for tissue impedance analysis. IEEE Transactions on Circuits and Systems II: Express Briefs, 62 (2) . pp. 154-158. ISSN 1549-7747 [Article] (doi:10.1109/tcsii.2014.2387632)

PDF - Final accepted version (with author's formatting)
Available under License Creative Commons Attribution 4.0.

Download (730kB) | Preview


Bioimpedance measurements are performed in a variety of medical applications including cancer detection in tissue. Such applications require wideband (typically 1 MHz) accurate ac current drivers with high output impedance and low distortion. This paper presents an integrated current driver that fulfills these requirements. The circuit uses negative feedback to accurately set the output current amplitude into the load. It was fabricated in a 0.35- μm complementary metal–oxide–semiconductor (CMOS) process technology, occupies a core area of 0.4 mm, and operates from ±2.5-V power supplies. For a maximum output current of 1mA p-p, the measured total harmonic distortion is below 0.1%, and the variability of the output current with respect to the load is below 0.5% up to 800 kHz increasing to 0.86% at 1 MHz. The current driver was tested for the detection of cancer sites from postoperative human colon specimens. The circuit is intended for use in active electrode applications.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences > Biophysics and Bioengineering group
Item ID: 21949
Useful Links:
Depositing User: Richard Bayford
Date Deposited: 07 Jun 2017 14:14
Last Modified: 29 Nov 2022 22:59
URI: https://eprints.mdx.ac.uk/id/eprint/21949

Actions (login required)

View Item View Item


Activity Overview
6 month trend
6 month trend

Additional statistics are available via IRStats2.