Lipoxin A4 selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression

Simoes, R. L,, De-Brito, N. M., Cunha-Costa, H., Morandi, V., Fierro, I. M., Roitt, Ivan and Barja-Fidalgo, C. (2017) Lipoxin A4 selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression. International Journal of Cancer, 140 (2) . pp. 346-357. ISSN 0020-7136 [Article] (doi:10.1002/ijc.30424)

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Abstract

In tumor microenvironments, the macrophage population is heterogeneous, but some macrophages can acquire tumor-promoting characteristics. These tumor-associated macrophages (TAM) exhibit an M2-like profile, with deficient production of NO and ROS, characteristics of pro-inflammatory M1 cytotoxic macrophages. The results show an unexpected effect of lipoxin, which induces in TAM a change from an M2- to an M1-like profile, thereby triggering tumor cell apoptosis and down-modulating the tumor progression.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences > Biomarkers for Cancer group
Item ID: 21780
Notes on copyright: This is the peer reviewed version of the following article: Simões, R. L., De-Brito, N. M., Cunha-Costa, H., Morandi, V., Fierro, I. M., Roitt, I. M. and Barja-Fidalgo, C. (2017), Lipoxin A4 selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression. Int. J. Cancer, 140: 346–357. doi:10.1002/ijc.30424, which has been published in final form at http://dx.doi.org/10.1002/ijc.30424. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
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Depositing User: Ivan Roitt
Date Deposited: 04 May 2017 15:46
Last Modified: 19 Jun 2021 06:12
URI: https://eprints.mdx.ac.uk/id/eprint/21780

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