Recent advances in arsenic trioxide encapsulated nanoparticles as drug delivery agents to solid cancers

Akhtar, Anam, Wang, Scarlet Xiaoyan, Ghali, Lucy ORCID logoORCID:, Bell, Celia M. ORCID logoORCID: and Wen, Xuesong ORCID logoORCID: (2017) Recent advances in arsenic trioxide encapsulated nanoparticles as drug delivery agents to solid cancers. Journal of Biomedical Research, 31 (3) . pp. 177-188. ISSN 1674-8301 [Article] (doi:10.7555/JBR.31.20160059)

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Since arsenic trioxide (ATO) was first approved as the front line therapy for acute promyelocytic leukemia (APL) 25 years ago, its anti-cancer properties for various malignancies have been under intense investigation. However, the clinical successes of ATO in treating hematological cancers have not been translated to solid cancers. This is due to arsenic’s rapid clearance by the body’s immune system before reaching the tumor site. Several attempts have henceforth been made to increase its bioavailability toward solid cancers without increasing its dosage albeit without much success. This review summarizes the past and current utilization of ATO in the medical field with primary focus on the implementation of nanotechnology for ATO delivery to solid cancer cells. Different approaches that have been employed to increase arsenic’s efficacy, specificity and bioavailability to solid cancer cells were evaluated and compared. The potential of combining different approaches or tailoring delivery vehicles to target specific types of solid cancers according to individual cancer characteristics and arsenic chemistry was proposed and discussed.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
Item ID: 20854
Notes on copyright: © 2017 by the Journal of Biomedical Research. All rights reserved
This is an open access article under the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited.
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Depositing User: Song Wen
Date Deposited: 31 Oct 2016 11:25
Last Modified: 29 Nov 2022 20:53

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