Evaluation of geometrical effects of microneedles on skin penetration by CT scan and finite element analysis

Loizidou, Erika ORCID logoORCID: https://orcid.org/0000-0002-4834-6639, Inoue, Nicholas T., Ashton-Barnett, Johnny, Barrow, David A. and Allender, Chris J. (2016) Evaluation of geometrical effects of microneedles on skin penetration by CT scan and finite element analysis. European Journal of Pharmaceutics and Biopharmaceutics, 107 . pp. 1-6. ISSN 0939-6411 [Article] (doi:10.1016/j.ejpb.2016.06.023)

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Computerized tomography (CT scan) imaging and finite element analysis were employed to investigate how the geometric composition of microneedles affects their mechanical strength and penetration characteristics. Simulations of microneedle arrays, comprising triangular, square and hexagonal microneedle base, revealed a linear dependence of the mechanical strength to the number of vertices in the polygon base. A laser-enabled, micromoulding technique was then used to fabricate 3x3 microneedle arrays, each individual microneedle having triangular, square or hexagonal base geometries. Their penetration characteristics into ex-vivo porcine skin, were investigated for the first time by CT scan imaging. This revealed greater penetration depths for the triangular and square-based microneedles, demonstrating CT scan as a powerful and reliable technique for studying microneedle skin penetration.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
Item ID: 20161
Notes on copyright: © 2016. This author's accepted manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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Depositing User: Erika Loizidou
Date Deposited: 07 Jul 2016 11:45
Last Modified: 20 Aug 2020 20:58
URI: https://eprints.mdx.ac.uk/id/eprint/20161

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