Structural characterization and transdermal delivery studies on sugar microneedles: experimental and finite element modelling analyses

Loizidou, Erika ORCID: https://orcid.org/0000-0002-4834-6639, Williams, Nicholas. A., Barrow, David A., Eaton, Mark J., McCrory, John, Evans, Sam L. and Allender, Chris J. (2015) Structural characterization and transdermal delivery studies on sugar microneedles: experimental and finite element modelling analyses. European Journal of Pharmaceutics and Biopharmaceutics, 89 . pp. 224-231. ISSN 0939-6411 [Article] (doi:10.1016/j.ejpb.2014.11.023)

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Abstract

Dissolving microneedles are especially attractive for transdermal drug delivery as they are associated with improved patient compliance and safety. Furthermore, microneedles made of sugars offer the added benefit of biomolecule stabilisation making them ideal candidates for delivering biological agents such as proteins, peptides and nucleic acids. In this study, we performed experimental and finite element analyses to study the mechanical properties of sugar microneedles and evaluate the effect of sugar composition on microneedle ability to penetrate and deliver drug to the skin. Results showed that microneedles made of carboxymethylcellulose / maltose are superior to those made of carboxymethylcellulose / trehalose and carboxymethylcellulose / sucrose in terms of mechanical strength and the ability to deliver drug. Buckling was predicted to be the main mode of microneedle failure and the order of buckling was positively correlated to the Young’s modulus values of the sugar constituents of each microneedle.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
Item ID: 17599
Notes on copyright: © 2014. This author's accepted manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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Depositing User: Erika Loizidou
Date Deposited: 21 Sep 2015 16:33
Last Modified: 20 Aug 2020 20:51
URI: https://eprints.mdx.ac.uk/id/eprint/17599

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