A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship

Stordal, Britta K. ORCID logoORCID: https://orcid.org/0000-0002-7892-951X, Pavlakis, Nick and Davey, Ross (2007) A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship. Cancer Treatment Reviews, 33 (8) . pp. 688-703. ISSN 0305-7372 [Article] (doi:10.1016/j.ctrv.2007.07.013)

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We undertook a systematic review of the pre-clinical and clinical literature for studies investigating the relationship between platinum and taxane resistance. Medline was searched for (1) cell models of acquired drug resistance reporting platinum and taxane sensitivities and (2) clinical trials of platinum or taxane salvage therapy in ovarian cancer. One hundred and thirty-seven models of acquired drug resistance were identified. 68.1% of cisplatin-resistant cells were sensitive to paclitaxel and 66.7% of paclitaxel-resistant cells were sensitive to cisplatin. A similar inverse pattern was observed for cisplatin vs. docetaxel, carboplatin vs. paclitaxel and carboplatin vs. docetaxel. These associations were independent of cancer type, agents used to develop resistance and reported mechanisms of resistance. Sixty-five eligible clinical trials of paclitaxel-based salvage after platinum therapy were identified. Studies of single agent paclitaxel in platinum-resistant ovarian cancer where patients had previously recieved paclitaxel had a pooled response rate of 35.3%, n=232, compared to 22% in paclitaxel naïve patients n=1918 (p<0.01, Chi-squared). Suggesting that pre-treatment with paclitaxel may improve the response of salvage paclitaxel therapy. The response rate to paclitaxel/platinum combination regimens in platinum-sensitive ovarian cancer was 79.5%, n=88 compared to 49.4%, n=85 for paclitaxel combined with other agents (p<0.001, Chi-squared), suggesting a positive interaction between taxanes and platinum. Therefore, the inverse relationship between platinum and taxanes resistance seen in cell models is mirrored in the clinical response to these agents in ovarian cancer. An understanding of the cellular and molecular mechanisms responsible would be valuable in predicting response to salvage chemotherapy and may identify new therapeutic targets.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences > Biomarkers for Cancer group
Item ID: 14437
Notes on copyright: Attached is an author accepted manuscript version of an article, made available in this repository in accordance with the publisher's self-archiving policy. The final published version of the article appears in Cancer Treatment Reviews at http://dx.doi.org/10.1016/j.ctrv.2007.07.013
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Depositing User: Britta Stordal
Date Deposited: 08 Jan 2016 09:39
Last Modified: 30 Nov 2022 01:54
URI: https://eprints.mdx.ac.uk/id/eprint/14437

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