Artificial receptor-attached amphiphilic copolymer for barbiturate binding in aqueous media
Loizidou, Erika 
ORCID: https://orcid.org/0000-0002-4834-6639, Zeinalipour-Yazdi, Constantinos and Sun, Lifang
(2004)
Artificial receptor-attached amphiphilic copolymer for barbiturate binding in aqueous media.
Biomacromolecules, 5
(5)
.
pp. 1647-1652.
ISSN 1525-7797
[Article]
(doi:10.1021/bm0497320)
Abstract
A water-soluble self-associating amphiphilic copolymer was employed to provide a microenvironment for the solvation of a hydrogen-bonding barbiturate artificial receptor, to facilitate molecular recognition in water. The receptor-attached amphiphilic polymer (RP) was synthesized through random copolymerization of 3% (mol) barbiturate receptor-monomer, 70% (mol) 3-sulfopropyl methacrylate, and 27% (mol) n-dodecyl acrylate. Difference UV spectra of pH 6.5 aqueous solutions of phenobarbital and receptor-polymer (RP) gave peaks and valleys at 272 and 301 nm respectively, consistent with binding characteristics of monomeric barbiturate receptors in chloroform. Specific association between phenobarbital and the receptor-polymer was further indicated based on investigations of a receptor-free control polymer (CP) of similar polar/nonpolar monomer ratio. Micellar electrokinetic chromatography was applied for studying polymer-phenobarbital association, by capillary electrophoresis.
| Item Type: | Article |
|---|---|
| Research Areas: | A. > School of Science and Technology > Natural Sciences |
| Item ID: | 14364 |
| Depositing User: | Erika Loizidou |
| Date Deposited: | 05 Mar 2015 15:01 |
| Last Modified: | 13 Oct 2016 14:32 |
| URI: | https://eprints.mdx.ac.uk/id/eprint/14364 |
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