Artificial receptor-attached amphiphilic copolymer for barbiturate binding in aqueous media

Loizidou, Erika ORCID logoORCID:, Zeinalipour-Yazdi, Constantinos and Sun, Lifang (2004) Artificial receptor-attached amphiphilic copolymer for barbiturate binding in aqueous media. Biomacromolecules, 5 (5) . pp. 1647-1652. ISSN 1525-7797 [Article] (doi:10.1021/bm0497320)


A water-soluble self-associating amphiphilic copolymer was employed to provide a microenvironment for the solvation of a hydrogen-bonding barbiturate artificial receptor, to facilitate molecular recognition in water. The receptor-attached amphiphilic polymer (RP) was synthesized through random copolymerization of 3% (mol) barbiturate receptor-monomer, 70% (mol) 3-sulfopropyl methacrylate, and 27% (mol) n-dodecyl acrylate. Difference UV spectra of pH 6.5 aqueous solutions of phenobarbital and receptor-polymer (RP) gave peaks and valleys at 272 and 301 nm respectively, consistent with binding characteristics of monomeric barbiturate receptors in chloroform. Specific association between phenobarbital and the receptor-polymer was further indicated based on investigations of a receptor-free control polymer (CP) of similar polar/nonpolar monomer ratio. Micellar electrokinetic chromatography was applied for studying polymer-phenobarbital association, by capillary electrophoresis.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
Item ID: 14364
Depositing User: Erika Loizidou
Date Deposited: 05 Mar 2015 15:01
Last Modified: 13 Oct 2016 14:32

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