Evaluation of β-alanine- and GABA-substituted peptides as inhibitors of disease-linked protein aggregation

Madine, Jillian, Wang, Xiaoyan, Brown, David R. and Middleton, David A. (2009) Evaluation of β-alanine- and GABA-substituted peptides as inhibitors of disease-linked protein aggregation. ChemBioChem, 10 (12) . pp. 1982-1987. ISSN 1439-4227 [Article] (doi:10.1002/cbic.200900219)

Abstract

Inhibition of amyoid formation - the β-peptide way: Introducing β-amino acids into short peptides is presented as a novel method of preventing aggregation of amyloid proteins. The data suggest a common precursor to design agents to treat Lewy body disease, Alzheimer's and type 2 diabetes.

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