Visualisation of the complexome.

Li, Simone and Xu, Kai and Wilkins, Marc (2010) Visualisation of the complexome. In: Human Proteome Organisation 9th Annual World Congress, I9th-23rd September 2010., Sydney Convention and Exhibition centre.

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Abstract

Proteins and other molecules interact with each other to form macromolecular complexes, which are the functional units inside the cell. Together, these make up the complexome. To date, there are 4 large-scale datasets for protein complexes in Saccharomyces cerevisiae. These were established by affinity purification and mass spectrometry. Of these, one featured protein sharing between complexes (Gavin et al.1). In this study, they proposed a ʻcore-module-attachmentʼ model. Core proteins are always present within a complex. Attachment proteins are single proteins that are sometimes but not always in a complex. Modules are groups of two or more strongly associated attachment proteins present in more than one complex. The aim of this study is to visualise the complexome as a network. This should provide a unique ʻhigh-levelʼ and biologically relevant view of the interactome.

Item Type:Conference or Workshop Item (Poster)
Research Areas:School of Science and Technology > Computer and Communications Engineering
ID Code:7041
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Deposited On:21 Feb 2011 13:17
Last Modified:03 Aug 2014 04:16

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