Gonadotropins and gonadotropin receptors: evolutional genetics, signalling mechanisms, extra gonadal function and roles in oncogenesis.

Iles, Ray K. and Butler, Stephen A. (2010) Gonadotropins and gonadotropin receptors: evolutional genetics, signalling mechanisms, extra gonadal function and roles in oncogenesis. Molecular and cellular endocrinology. , 329 (1). pp. 1-2. ISSN 0303-7207

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Abstract

Gonadotropin and gonadotropin receptors, at first glance to the uninitiated, would suggest a conference concerned with reproduction and reproductive biology. The 1st International Conference on Gonadotropins and their Receptors (ICGR I) proved that this was far from the case. As evidenced by the diverse papers presented there and published in the First ICGR special issue of Molecular CellularEndocrinology (2007), there was clearly more to the topic than this simplistic view would lead you to believe. It became clear that the field of gonadotropin research has evolved in more ways than one and, as a result, ICGR II become slightly more thematic. A greater emphasis was placed on extragonadal actions of the gonadotropins and their receptors, the possible molecular basis of growth factor cross talk across the receptors and how this may underlay oncogenesis in reproductive and non reproductive tissues. What is now becoming evident is that this simple molecular segregation and structural classification may not be a firm and unbreakable divide in the gonadotropin and receptor arena; as with all things in nature variation on a theme abounds,system change and adapt.

Item Type:Article
Research Areas:School of Science and Technology > Natural Sciences
Citations on ISI Web of Science:0
ID Code:6896
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Deposited On:18 Jan 2011 09:48
Last Modified:10 Oct 2013 09:15

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