Physical mapping of the rat MHC class II genes shows a high level of inter-species conservation.

Carter, Clare A. and Murphy, Gerrard and Fabre, John W. and Lund, Torben (1994) Physical mapping of the rat MHC class II genes shows a high level of inter-species conservation. Genomics, 22 (2). pp. 451-455. ISSN 0888-7543

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Abstract

We report here a pulsed-field gel electrophoresis map of the rat major histocompatibility complex (MHC) class II region. Using probes for the recently discovered Tap-1 and Tap-2 genes and the different MHC class II genes, we found the gene order in the rat MHC (RT1) region to be RT1.H-Tap-1-Tap-2-Bb-Ba-Db-Da. Moreover, the distance between the Tap-1 and the RT1.Da genes is approximately 150 kb. This, together with recent mapping of the RT1 class III region, demonstrates an extensive colinearity in the MHC region of different species.

Item Type:Article
Research Areas:Middlesex University Schools and Centres > School of Science and Technology > Natural Sciences
ID Code:6694
Deposited On:09 Nov 2010 15:09
Last Modified:30 Jul 2014 13:03

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