Physical mapping of the rat MHC class II genes shows a high level of inter-species conservation.
Carter, Clare A. and Murphy, Gerrard and Fabre, John W. and Lund, Torben (1994) Physical mapping of the rat MHC class II genes shows a high level of inter-species conservation. Genomics, 22 (2). pp. 451-455. ISSN 0888-7543
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We report here a pulsed-field gel electrophoresis map of the rat major histocompatibility complex (MHC) class II region. Using probes for the recently discovered Tap-1 and Tap-2 genes and the different MHC class II genes, we found the gene order in the rat MHC (RT1) region to be RT1.H-Tap-1-Tap-2-Bb-Ba-Db-Da. Moreover, the distance between the Tap-1 and the RT1.Da genes is approximately 150 kb. This, together with recent mapping of the RT1 class III region, demonstrates an extensive colinearity in the MHC region of different species.
|Research Areas:||A. > School of Science and Technology > Natural Sciences|
|Depositing User:||Mrs Sue Black|
|Date Deposited:||09 Nov 2010 15:09|
|Last Modified:||13 Oct 2016 14:21|
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