Amplification or rearrangement of the beta-human chorionic gonadotrophin (beta-hCG)--human LH gene cluster is not responsible for the ectopic production of beta-hCG by bladder tumour cells.

Iles, Ray K. and Czepulkowski, B. H. and Young, B. D. and Chard, Tim (1989) Amplification or rearrangement of the beta-human chorionic gonadotrophin (beta-hCG)--human LH gene cluster is not responsible for the ectopic production of beta-hCG by bladder tumour cells. Journal of molecular endocrinology, 2 (2). pp. 113-117. ISSN 0952-5041

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Abstract

The beta-subunit of human chorionic gonadotrophin (hCG) is coded on chromosome 19 by the beta-hCG-hLH gene cluster. Genomic DNA has been isolated from bladder tumour cell lines which ectopically express beta-hCG. The beta-hCG-hLH gene cluster was probed for possible rearrangement or amplification and cells karyotyped for chromosome 19 abnormalities. No rearrangement or amplification of the gene cluster and no consistent abnormalities of chromosome 19 were found. The expression of beta-hCG by bladder tumours is therefore likely to be the result of altered gene regulation and not a rearrangement or amplification of this gene cluster.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
ISI Impact: 20
Item ID: 6113
Depositing User: Professor Ray Iles
Date Deposited: 23 Jun 2010 13:23
Last Modified: 16 Dec 2015 16:37
URI: http://eprints.mdx.ac.uk/id/eprint/6113

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