In vitro secretion of human chorionic gonadotrophin by bladder tumour cells.
Iles, Ray K. and Oliver, R.T.D. and Kitau, M. and Walker, C. and Chard, Tim (1987) In vitro secretion of human chorionic gonadotrophin by bladder tumour cells. British journal of cancer, 55 (6). pp. 623-626. ISSN 0007-0920
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Human chorionic gonadotrophin (hCG) and alphafetoprotein (AFP) were measured in culture media from a panel of 29 cell lines including 9 bladder carcinomas, 5 'normal' bladder epithelia, 10 germ cell tumours, and 5 miscellaneous tumours and 'normal' cell lines. In 7 of the 9 bladder carcinomas and 4 of the 5 'normal' bladder epithelia, the media contained hCG at levels ranging from between 34 and 3,600 IU l(-1). All other cell lines, including the 10 germ cell tumour lines gave negative results for hCG. These findings indicate that in vitro secretion of hCG is a common feature of normal and neoplastic bladder transitional epithelia, and support the hypothesis that parts of the genito-urinary epithelium have a potential for hCG production.
|Research Areas:||School of Science and Technology > Natural Sciences|
|Permissions granted by publisher:||PMC free access|
|Deposited On:||23 Jun 2010 13:09|
|Last Modified:||26 Jul 2014 17:51|
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