Bony metastases from breast cancer: a study of foetal antigen 2 as a blood tumour marker.
Cheung, Kwok-Leung and Iles, Ray K. and Robertson, John (2010) Bony metastases from breast cancer: a study of foetal antigen 2 as a blood tumour marker. World Journal of Surgical Oncology, 8 (38). ISSN 1477-7819
Official URL: http://www.wjso.com/content/8/1/38
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Background : Foetal antigen 2 (FA-2), first isolated in the amniotic fluid, was shown to be the circulating form of the aminopropeptide of the alpha 1 chain of procollagen type I. Serum concentrations of FA-2 appeared to be elevated in a number of disorders of bone metabolism. This paper is the first report of its role as a marker of bone metabolism in metastatic breast cancer. Methods: Serum FA-2 concentrations were measured by radioimmunoassay in 153 women with different stages of breast cancer and in 34 normal controls. Results: Serum FA-2 was significantly elevated in women with bony metastases (p < 0.015). Its levels were not significantly different among women with non-bony metastases, with non-metastatic disease, as well as among normal controls. Conclusions: FA-2 is a promising blood marker of bone metabolism. Further studies to delineate its role in the diagnosis and management of bony metastases from breast cancer are required.
|Research Areas:||Science & Technology > Biomedical Science|
|Citations on ISI Web of Science:||0|
|Permissions granted by publisher:||open access item|
|Deposited On:||10 Jun 2010 14:44|
|Last Modified:||11 Oct 2013 05:24|
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