Bony metastases from breast cancer: a study of foetal antigen 2 as a blood tumour marker.

Cheung, Kwok-Leung and Iles, Ray K. and Robertson, John (2010) Bony metastases from breast cancer: a study of foetal antigen 2 as a blood tumour marker. World Journal of Surgical Oncology, 8 (38). ISSN 1477-7819


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Background : Foetal antigen 2 (FA-2), first isolated in the amniotic fluid, was shown to be the circulating form of the aminopropeptide of the alpha 1 chain of procollagen type I. Serum concentrations of FA-2 appeared to be elevated in a number of disorders of bone metabolism. This paper is the first report of its role as a marker of bone metabolism in metastatic breast cancer. Methods: Serum FA-2 concentrations were measured by radioimmunoassay in 153 women with different stages of breast cancer and in 34 normal controls. Results: Serum FA-2 was significantly elevated in women with bony metastases (p < 0.015). Its levels were not significantly different among women with non-bony metastases, with non-metastatic disease, as well as among normal controls. Conclusions: FA-2 is a promising blood marker of bone metabolism. Further studies to delineate its role in the diagnosis and management of bony metastases from breast cancer are required.

Item Type:Article
Research Areas:A. Middlesex University Schools and Centres > School of Science and Technology > Natural Sciences
Citations on ISI Web of Science:0
ID Code:6069
Permissions granted by publisher:open access item
Deposited On:10 Jun 2010 14:44
Last Modified:20 Jul 2014 08:03

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