Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease.
Rooprai, Harcharan K. and Christidou, M. and Datla, K. P. and Widmer, W. W. (2001) Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease. Neuroreport, 12 (17). pp. 3871-3875. ISSN 09594965
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This was the first study to give evidence that a citrus flavonoid (tangeretin) crosses the rat blood-brain-barrier and reduces the loss of TH+ cells and dopamine after 6-OHDA lesion in a model for PD. It showed that there was differential regional distribution of tangeretin within the brain and was neuroprotective.
|Research Areas:||School of Science and Technology > Natural Sciences|
|Citations on ISI Web of Science:||46|
|Deposited On:||24 Nov 2008 12:39|
|Last Modified:||06 Feb 2013 11:45|
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