Association between large-scale genomic homozygosity without chromosomal loss and nonseminomatous germ cell tumor development

Lu, Yong-Jie and Yang, Jinshu and Noel, Elodie and Skoulakis, Spyros and Chaplin, Tracy and Raghavan, Manoj and Purkis, Trisha and Mcintyre, Alan and Kudahetti, Sakunthala C. and Naase, Mahmoud and Berney, Dan and Shipley, Janet and Oliver, R. T. and Young, Bryan D. (2005) Association between large-scale genomic homozygosity without chromosomal loss and nonseminomatous germ cell tumor development. Cancer Research, 65 (20). pp. 9137-9141. ISSN 1538-7445

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Abstract

The genotype of a tumor determines its biology and clinical behavior. The genetic alterations associated with the unique embryonal morphology of nonseminomatous subtypes of testicular germ cell tumors remain to be established. Using single nucleotide polymorphism microarray analysis, we found in all of the 15 nonseminomas analyzed, large-scale chromosomal homozygosities, most of which were not associated with relative chromosome loss. This unusual genotype, distinguishing nonseminoma from seminomas and other human tumors, may be associated with the special embryonal development morphologic transition of this malignancy. Based on these genetic data, we hypothesized a new potential origin of nonseminomas through sperm fusion. Nonrandom involvement of certain chromosomes also suggests that genes on these chromosome regions may play an important role in nonseminoma development.

Item Type:Article
Research Areas:Middlesex University Schools and Centres > School of Science and Technology > Natural Sciences
Citations on ISI Web of Science:10
ID Code:510
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Deposited On:21 Nov 2008 16:51
Last Modified:11 Mar 2014 08:25

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