Insulin-related growth factor binding protein-1 levels in ovum donation pregnancies.
Brooks, A. A. and Johnson, Mark R. and Hills, Frank and Chard, Tim and Irvine, R. and Abdalla, H. I. (1995) Insulin-related growth factor binding protein-1 levels in ovum donation pregnancies. European Journal of Obstetrics, Gynaecology and Reproductive Biology, 59 (1). pp. 91-94. ISSN 0921-8750
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The finding that endometrial maturation may be delayed following hormone replacement therapy has suggested that a generalised endometrial dysfunction may exist in ovum recipients. In order to investigate this suggestion further, circulating levels of IGFBP-1 were measured in samples taken throughout pregnancies conceived either spontaneously or following ovum donation. When analysed at two-weekly intervals, the serum levels of IGFBP-1 in ovum donation pregnancies failed to show the expected peak towards the end of the first trimester and were significantly reduced at week ten (U = 364.5, p = 0.0002) and twelve (U = 138.0, p = 0.0047). For the remainder of pregnancy, circulating IGFBP-1 levels were similar in both groups. The birth weight of children born to the ovum donation group was not significantly different from a normal control group, suggesting that circulating levels of IGFBP-1 in early pregnancy do not reflect local function and that IGFBP-1 does not have an essential function (in relation to birth weight) in early pregnancy.
|Keywords (uncontrolled):||IGFBP-1 Pregnancy IVF Ovum Donation|
|Research Areas:||Science & Technology > Biomedical Science|
|Citations on ISI Web of Science:||2|
|Deposited On:||25 Mar 2010 14:11|
|Last Modified:||06 Feb 2013 11:45|
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