Superovulation, IGFBP-1 and birth weight.

Johnson, Mark R. and Irvine, R. and Hills, Frank and Bolton, V. N. and Abbas, A. A. and Brooks, A. A. and Allman, A. C. and Chard, Tim and Nicolaides, K. H. (1995) Superovulation, IGFBP-1 and birth weight. European Journal of Obstetrics, Gynaecology and Reproductive Biology, 59 (2). pp. 193-195. ISSN 0921-8750

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In this study, the effect of superovulation on the circulating levels of insulin-like growth factor binding protein-1 (IGFBP-1) has been investigated. IGFBP-1 levels were measured in singleton pregnancies achieved either naturally (n = 203) or following superovulation, in-vitro fertilisation and embryo transfer (IVF-ET) with either pituitary desensitisation with buserelin and superovulation with human menopausal gonadotrophin (b/hMG) followed by IVF-ET (n = 15) or with clomiphene citrate and hMG (CC/hMG) followed by IVF-ET (n = 15, 1st trimester only). The circulating levels of IGFBP-1 were similar in all three groups during the first trimester, and in both normal and b/hMG pregnancies in the second, but were significantly higher during the third trimester in b/hMG pregnancies than in normal pregnancies (P = 0.0002). The birth weights were significantly lower in the b/hMG group (P = 0.04), but not in the CC/hMG group compared with natural conceptions. Gestational age at delivery was similar in control and b/hMG pregnancies, but significantly reduced in CC/hMG pregnancies (P = 0.04). These data suggest that pregnancies achieved following superovulation with b/hMG are associated with elevated levels of IGFBP-1 during the third trimester of pregnancy and reduced birth weight.

Item Type: Article
Keywords (uncontrolled): IGFBP-1 Pregnancy birthweight
Research Areas: A. > School of Science and Technology > Natural Sciences > Biomarkers for Cancer group
A. > School of Science and Technology > Natural Sciences > Reproductive Biology group
A. > School of Health and Education > Centre for Investigative and Diagnostic Oncology
A. > School of Science and Technology > Natural Sciences
ISI Impact: 11
Item ID: 4597
Useful Links:
Depositing User: Frank Hills
Date Deposited: 26 Mar 2010 10:09
Last Modified: 13 Oct 2016 14:18

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