Measurement of the diffusion coefficient within lumbar intervertebral disks using high dose gadodiamide enhanced MRI.
Callaghan, Martina and Herlihy, Amy H. and Allsop, Joanna and Oatridge, Angela and Larkman, David J. and Hajnal, Joseph V. and Hughes, Sean P. F. and Bydder, Graeme (2002) Measurement of the diffusion coefficient within lumbar intervertebral disks using high dose gadodiamide enhanced MRI. In: 10th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine, 18-24 May 2002, Hawaii, U.S.A..
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Official URL: http://cds.ismrm.org/ismrm-2002/PDF7/1840.PDF
The lumbar intervertebral disks are the largest avascular structure in the human body and there is considerable interest in the study of nutrient transport into and withm these disks. High dose Gadolinium chelates have been used with MRI to visualize transport via TI change. In this work the subsequent enhancement has been modeled with a 1D solution of the diffusion equation to estimate the diffusion coefficient of Gadodiamide within the disks. Diffusion coefficients of 1.67x10-10m2s-1 and 1.8 x 10-10m2s-1 have been calculated from single disks in two healthy volunteers.
|Item Type:||Conference or Workshop Item (Paper)|
|Research Areas:||School of Science and Technology > Natural Sciences|
|Deposited On:||11 Feb 2010 11:38|
|Last Modified:||06 Feb 2013 11:45|
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