Designing a new generation of anti-hCG vaccines for cancer therapy
Delves, Peter J. and Iles, Ray K. and Roitt, Ivan and Lund, Torben (2007) Designing a new generation of anti-hCG vaccines for cancer therapy. Molecular and cellular endocrinology, 260-26 . pp. 276-281. ISSN 0303-7207
Full text is not in this repository.
Official URL: http://tinyurl.com/yazpfs8
This item is available in the Library Catalogue
The heterodimeric ‘pregnancy-specific’ hormone human chorionic gonadotropin (hCG) has been used as the basis for a contraceptive vaccine. More recently, the observation that hCG, particularly in the form of the β-chain expressed in the absence of α-chain, is aberrantly expressed in a number of different tumors has opened up a second potential application for such vaccines. Drawbacks of the currently available vaccines are that they are either relatively weakly immunogenic or that they induce antibodies that cross-react with human leuteinizing hormone (hLH). We have explored the possibility of creating mutated versions of the hCG β-chain with improved immunologic properties.
|Research Areas:||Middlesex University Schools and Centres > School of Science and Technology > Natural Sciences|
Middlesex University Schools and Centres > School of Science and Technology > Natural Sciences > Biomarkers for Cancer group
|Deposited On:||12 Feb 2010 11:30|
|Last Modified:||24 Nov 2014 16:41|
Repository staff only: item control page
Full text downloads (NB count will be zero if no full text documents are attached to the record)
Downloads per month over the past year