Designing a new generation of anti-hCG vaccines for cancer therapy

Delves, Peter J. and Iles, Ray K. and Roitt, Ivan and Lund, Torben (2007) Designing a new generation of anti-hCG vaccines for cancer therapy. Molecular and cellular endocrinology, 260-26 . pp. 276-281. ISSN 0303-7207

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Abstract

The heterodimeric ‘pregnancy-specific’ hormone human chorionic gonadotropin (hCG) has been used as the basis for a contraceptive vaccine. More recently, the observation that hCG, particularly in the form of the β-chain expressed in the absence of α-chain, is aberrantly expressed in a number of different tumors has opened up a second potential application for such vaccines. Drawbacks of the currently available vaccines are that they are either relatively weakly immunogenic or that they induce antibodies that cross-react with human leuteinizing hormone (hLH). We have explored the possibility of creating mutated versions of the hCG β-chain with improved immunologic properties.

Item Type:Article
Research Areas:Middlesex University Schools and Centres > School of Science and Technology > Natural Sciences
Middlesex University Schools and Centres > School of Science and Technology > Natural Sciences > Biomarkers for Cancer group
ID Code:3969
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Deposited On:12 Feb 2010 11:30
Last Modified:24 Nov 2014 16:41

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