The major hormone-specific epitopes on human chorionic gonadotropin
Charrel-Dennis, Marie and Jackson, A. M. and Lund, Torben and Lapthorn, Adrian J. and Berger, Peter and Roitt, Ivan and Delves, Peter J. (2004) The major hormone-specific epitopes on human chorionic gonadotropin. Journal of molecular endocrinology, 32 (2). pp. 571-581. ISSN 0952-5041
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The hormone human chorionic gonadotrophin (hCG) shows extensive sequence homology with LH. Thus, many of the antigenic epitopes on hCG are shared with LH, leading to immunological cross-reaction between these two hormones. Anti-fertility and anti-cancer vaccines based upon hCG should ideally target only the hCG-specific epitopes. The hCG-unique linear epitopes located in the C-terminal peptide of the hCG beta-chain are well characterised. In contrast, the hCG-specific discontinuous epitopes, termed beta1, beta6 and beta7, have remained poorly defined. By generating hCG beta-chain molecules containing single amino acid substitutions we have identified R10, N13, R60 and Q89 as being important in the formation of the beta1 epitope, with R60 providing a particularly dominant residue. We also show that the amino acid residue Q89 contributes to the beta7 epitope, whilst D61 plays a role in both the beta6 and beta7 epitopes.
|Research Areas:||School of Science and Technology > Natural Sciences|
|Deposited On:||02 Feb 2010 08:55|
|Last Modified:||22 Oct 2013 07:43|
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