The immunological analysis of epitopes on hCG

Lund, Torben and Delves, Peter J. (1998) The immunological analysis of epitopes on hCG. Reproduction: the official journal of the Society for the Study of Fertility, 3 (2). pp. 71-76. ISSN 1470-1626

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The heterodimeric glycoprotein hormone, human chorionic gonadotropin, has been extensively characterized in terms of its recognition by mouse monoclonal antibodies. A number of different approaches have led to the definition of several epitope clusters on the surface of the molecule. These include epitopes located solely on the alpha- or beta-chain, some of which are masked when the two chains associate to form the holo-hormone. Additional epitopes comprise amino acids contributed by both the chains. In contrast to the extensive knowledge regarding B cell epitopes, the characterization of T cell epitopes on hCG has only recently begun to be explored.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
ISI Impact: 9
Item ID: 3902
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Depositing User: Mrs Sue Black
Date Deposited: 02 Feb 2010 08:43
Last Modified: 13 Oct 2016 14:17

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