The immunological analysis of epitopes on hCG
The heterodimeric glycoprotein hormone, human chorionic gonadotropin, has been extensively characterized in terms of its recognition by mouse monoclonal antibodies. A number of different approaches have led to the definition of several epitope clusters on the surface of the molecule. These include epitopes located solely on the alpha- or beta-chain, some of which are masked when the two chains associate to form the holo-hormone. Additional epitopes comprise amino acids contributed by both the chains. In contrast to the extensive knowledge regarding B cell epitopes, the characterization of T cell epitopes on hCG has only recently begun to be explored.
|Research Areas:||A. > School of Science and Technology > Natural Sciences|
|Depositing User:||Mrs Sue Black|
|Date Deposited:||02 Feb 2010 08:43|
|Last Modified:||15 Dec 2015 12:37|
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