A deletion panel of the long arm of the X chromosome: subregional localization of 22 DNA probes.
Yang, H. M. and Lund, Torben and Niebuhr, E. and Norby, S. and Schwartz, M. and Shen, L. (1990) A deletion panel of the long arm of the X chromosome: subregional localization of 22 DNA probes. Human Genetics, 85 (1). pp. 25-30. ISSN 0340-6717
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Two males and two females with different but overlapping deletions on the proximal long arm of the X chromosomes have been investigated. Their karyotypes, which have been well characterized by high resolution banding techniques, are 46,Y,del(X)(pterrarrq21.1:: q21.33rarrqter); 46,Y,del(X) (pterrarrq21.2::q21.31rarrqter); 46,X,del(X) (pterrarrq21.31::q24.3rarrqter) and 46,X,del (X)(pterrarrq21.1:). A deletion panel, which makes it possible to subdivide the long arm of the X chromosome into seven subregions, has been established using the genomic DNA from the four families, and applied to the fine subregional localization of the loci for 22 DNA probes. Based on the results obtained, the possible location of the loci in question has been narrowed down considerably, in some cases to an area of only 5% of the previously assigned region; hybridization to Southern blots of a panel with well-characterized chromosome deletions is thus a powerful means of localizing DNA probes, especially with respect to the X probes.
|Research Areas:||Middlesex University Schools and Centres > School of Science and Technology > Natural Sciences|
|Citations on ISI Web of Science:||3|
|Deposited On:||02 Feb 2010 08:39|
|Last Modified:||06 Feb 2013 11:45|
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