Restriction fragment length polymorphism in the major histocompability complex of the non-obese diabetic mouse

Lund, Torben and Simpson, Elizabeth and Cooke, Anne (1990) Restriction fragment length polymorphism in the major histocompability complex of the non-obese diabetic mouse. Journal of Autoimmunity, 3 (3). pp. 289-298. ISSN 0896-8411

Full text is not in this repository.

This item is available in: Library Catalogue

Abstract

The inbred non-obese diabetic (NOD) mouse is a spontaneous model for insulin-dependent diabetes mellitus (IDDM). As in man and BB rats, IDDM in the NOD mouse has an autoimmune aetiology. The disease is controlled by several genes, one of which, Idd-1, has been mapped to the major histocompatibility complex (MHC) on chromosome 17. However, Idd-1 has not yet been identified. To facilitate the identification of Idd-1 we have further analysed the MHC region for restriction fragment length polymorphisms and we find that the NOD mouse has a distinct haplotype: H-2K1nod Kd Aβnod Aαd Eβnod Eαnod TNF-αb. In addition, the NOD mouse shows some similarities with the H-2b haplotype in the Q region, in that either the Q7 or the Q9 gene seems to be like that in the b-haplotype and that the Qa2 antigen is expressed, while other parts of this region are distinct from the b- as well as the d-haplotype. In contrast, the sister strain, the non-obese normal (NON) mouse, derived from the same cataract-prone line of mice as the NOD mouse, has an MHC Class I region indistinguishable from the b-haplotype, but the MHC Class II region is distinct from the NOD mouse as well as the b-, d- and k-haplotype.

Item Type: Article
Research Areas: A. > School of Science and Technology > Natural Sciences
Item ID: 3897
Depositing User: Mrs Sue Black
Date Deposited: 02 Feb 2010 08:24
Last Modified: 01 Dec 2015 15:57
URI: http://eprints.mdx.ac.uk/id/eprint/3897

Actions (login required)

Edit Item Edit Item