Characterization of a hepatitis A virus strain suitable for vaccine production

Fineschi, Nicoletta and Cavalieri, Filippo and Garelick, Hemda and Prugnola, Anna and Pellegrini, Vittoria and Zuckerman, Arie J. (1991) Characterization of a hepatitis A virus strain suitable for vaccine production. Journal of Hepatology, 13 . S146-S151. ISSN 0168-8278

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A novel isolate of hepatitis A virus, obtained from a clinical sample, has been adapted to grow on cultured human diploid cells. Growth and purification parameters have been optimized to obtain conditions suitable for the development of an inactivated vaccine. The entire viral genome was molecularly cloned, and the gene encoding the VP3 capsid protein was expressed in Escherichia coli. The resulting recombinant VP3 was used to obtain rabbit antisera which recognize the denatured protein in purified virion preparations. Nucleotide sequencing data are presented and compared to known sequences of different strains.

Item Type:Article
Research Areas:A. > School of Science and Technology > Natural Sciences
Citations on ISI Web of Science:2
ID Code:3732
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Deposited On:18 Jan 2010 15:24
Last Modified:13 Mar 2015 13:58

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