Serum concentrations of cancer antigen 125, placental alkaline phosphatase, cancer-associated serum antigen and free beta human chorionic gonadotrophin as prognostic markers for epithelial ovarian cancer
Ind, Thomas and Iles, Ray K. and Shepherd, John H. and Chard, Tim (1997) Serum concentrations of cancer antigen 125, placental alkaline phosphatase, cancer-associated serum antigen and free beta human chorionic gonadotrophin as prognostic markers for epithelial ovarian cancer. British Journal of Obstetrics and Gynaecology, 104 (9). pp. 1024-1029. ISSN 1470-0328
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To investigate the prognostic significance of elevated levels of cancer antigen 125 (CA125), placental alkaline phosphatase (PLAP), free beta human chorionic gonadotrophin (hCG) and cancer-associated serum antigen (CASA) in women with primary epithelial ovarian carcinoma.
Design A two year follow up study of survival.
Setting A tertiary care gynaecological oncology unit.
One hundred and eleven women with histologically confirmed epithelial ovarian cancer.
Main outcome measures -
Survival over a two year period.
Stage corrected log-rank 2 tests demonstrated a significant effect on survival for all four tumour markers (CA125 P= 0.0142 ; PLAP P < 0.0001 ; CASA P= 0.0098 ; hCG P= 0.0002 ). This was confirmed when each variable was fitted together with disease stage in Cox proportional hazard models. When fitted as multiple variables in a Cox proportional hazard model, the addition of free beta-hCG and CASA to disease stage, PLAP concentrations and CA125 levels did not demonstrate further prognostic value.
Levels of all four markers correlate with survival in patients with epithelial ovarian cancer. The combination of PLAP and CA125 concentrations together with disease stage may be used to predict survival but the addition of hCG and CASA levels do not give additional prognostic information.
|Research Areas:||A. > School of Science and Technology > Natural Sciences|
|Depositing User:||Devika Mohan|
|Date Deposited:||24 Dec 2009 06:22|
|Last Modified:||30 Sep 2015 15:12|
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