Hepatitis C viraemia in adults with type 2 autoimmune hepatitis.

Garson, Jeremy A. and Lenzi, M. and Ring, Christopher J. and Cassani, F. and Ballardini, G. and Briggs, M. and Tedder, Richard S. and Bianchi, F. B. (1991) Hepatitis C viraemia in adults with type 2 autoimmune hepatitis. Journal of medical virology, 34 (4). pp. 223-6. ISSN 0146-6615

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Sera from 14 patients with type 2 autoimmune hepatitis (anti-LKM1 positive) were investigated for evidence of hepatitis C virus (HCV) infection. Antibodies to HCV were detected in 13 patients by both commercial and "in-house" ELISAs and also by a second generation recombinant immunoblot assay. Nine of the 13 (69%) anti-HCV positive patients were shown to be viraemic by a polymerase chain reaction-based assay for serum HCV RNA. Neither anti-HCV nor serum HCV RNA were detected in any of 6 controls with primary biliary cirrhosis or in 39 healthy blood donors. These findings strongly suggest a role for HCV in the pathogenesis of type 2 autoimmune hepatitis.

Item Type:Article
Research Areas:A. > School of Science and Technology > Natural Sciences
ID Code:3332
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Deposited On:03 Dec 2009 14:34
Last Modified:24 Mar 2015 13:11

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