Hepatitis C viraemia in United Kingdom blood donors. A multicentre study.
Garson, Jeremy A. and Clewley, J. P. and Simmonds, P. and Zhang, L. Q. and Mori, J. and Ring, Christopher J. and Follett, E. A. and Dow, B. C. and Martin, Stewart and Gunson, H. (1992) Hepatitis C viraemia in United Kingdom blood donors. A multicentre study. Vox sanguinis, 62 (4). pp. 218-23. ISSN 0042-9007
Full text is not in this repository.
Of 10,633 blood donations tested in three regional blood transfusion centres with two commercial first generation screening assays for antibodies to the hepatitis C virus (HCV), 65 (0.61%) were found to be repeatedly reactive in one or both assays. Five of the 65 were confirmed positive by recombinant immunoblot assay (Ortho RIBA-2) and a further 4 were judged indeterminate. All 5 RIBA-2 positive donations and 1 of the 4 RIBA-2 indeterminates were shown to be viraemic by HCV-RNA polymerase chain reaction (PCR) assays performed at three independent reference laboratories. The remaining 56 screen test reactive donations proved negative by RIBA-2 and, with 1 exception, negative by PCR. We conclude that while first generation anti-HCV screening assays generate a high proportion of false reactions when screening low prevalence populations, results of the RIBA-2 confirmatory test correlate well with PCR findings and thus indirectly with both hepatitis C viraemia and infectivity.
|Research Areas:||Middlesex University Schools and Centres > School of Science and Technology > Computer Science|
|Deposited On:||03 Dec 2009 14:24|
|Last Modified:||04 Dec 2014 17:22|
Repository staff only: item control page
Full text downloads (NB count will be zero if no full text documents are attached to the record)
Downloads per month over the past year